pyridoxine hydrochloride

CLINICAL USE

Vitamin B6

DOSE IN NORMAL RENAL FUNCTION

Deficiency:

20 to 50 : mg up to 3 times daily Prophylaxis against isoniazid neuropathy:

10 to 20 : mg daily; 50 mg 3 times daily for treatmentIdiopathic sideroblastic anaemia: 100– 400 mg daily in divided dosesPremenstrual syndrome: 50–100 mg daily

PHARMACOKINETICS

Molecular weight :205.6

%Protein binding :High (as pyridoxal and pyridoxal phosphate)

%Excreted unchanged in urine : No data

Volume of distribution (L/kg) :No data

half-life – normal/ESRD (hrs) :15–20 days

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unknown dialysability. Dose as in normal renal function

HD :Dialysed. Dose as in normal renal function

HDF/high flux :Dialysed. Dose as in normal renal function

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

None known

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

–

OTHER INFORMATION

Long-term use of pyridoxine in doses greater than 200 mg daily has been associated with neuropathy

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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